Dynamic optimization of metabolic networks coupled with gene expression
نویسندگان
چکیده
منابع مشابه
Dynamic optimization of metabolic networks coupled with gene expression.
The regulation of metabolic activity by tuning enzyme expression levels is crucial to sustain cellular growth in changing environments. Metabolic networks are often studied at steady state using constraint-based models and optimization techniques. However, metabolic adaptations driven by changes in gene expression cannot be analyzed by steady state models, as these do not account for temporal c...
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1Department of Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany. 2Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. 3 Institute of Computer Science, University of Heidelberg, 69120 Heidelberg, Germany. 4Institute for Human Genetics, University of Heidelberg, ...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2015
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2014.10.035